b'OverviewPioneeringRecognized by the National Cancer InstituteResearch with a SPORE Award In 1992, the National Cancer Institute (NCI) established the Specialized Program of Research Excellence (SPORE). A cornerstone of NCIs efforts to promote collaborative, interdisciplinary translational research, SPORE awards are designed to enable the rapid movement of fundamental scientific findings into clinical settings. Highly prized and selectively awarded, they typically focus on a specific area of cancer, such as breast, lung, or kidney cancer.Among the current 63 SPORE awards in the U.S., two focus on kidney cancerone at the Simmons Cancer Center and the other at the Dana-Farber Cancer Institute/Harvard Cancer Center (Boston).National Cancer Institute Specialized Program of Research Excellence Award (SPORE)Award term: 2016-2021 | Amount: $11 millionPrincipal Investigator: James Brugarolas, M.D., Ph.D. PROJECT 1 PROJECT 2Projects Administration Core Advanced Imaging CoreOrganizing hub of the SPORE. Developing and applying new 1 Evaluation of a promising3 Predicting aggressivenessJames Brugarolas, M.D., Ph.D. technologies to characterize first-in-class drug thatin small kidney tumors byArthur Sagalowsky, M.D. kidney cancer and its Adminblocks the HIF-2 protein,understanding their higherRene McKay, Ph.D. variants noninvasively.P Core arguably the main driverneed for nutrients. Ivan Pedrosa, M.D., Ph.D. D a ta h C r Pathology Core Robert Lenkinski, Ph.D.t a A oe of kidney cancer. Ralph DeBerardinis, M.D., Ph.D.d alytics Core James Brugarolas, M.D., Ph.D. Ivan Pedrosa, M.D., Ph.D. Integrating genetics, biology,DevelopmentalA nv a nc Kevin Courtney, M.D., Ph.D. Vitaly Margulis, M.D. and new technologies to identifyResearch Programe and define distinct subtypes.d Im ging Core Ivan Pedrosa, M.D., Ph.D. Seed funding supporting a CareerDefining a new subtypePayal Kapur, M.D. innovation in translation.Enhancement Understanding how4 of childhood kidneyDinesh Rakheja, M.D.Developmental 2 BAP1 loss causescancer and developingCareer Enhancement PROJECT 4 aggressive kidneytailored therapies. Data Analytics Core ProgramResearchPROJECT 3 Pioneering new technologies cancer with developmentJames Amatruda, M.D., Ph.D. designed to leverageSeed funding to develop the of counteractingJoshua Mendell, M.D., Ph.D. artificial intelligence. next generation of kidney cancer researchers.therapeutic strategies. Yang Xie, Ph.D.Payal Kapur, M.D.Tao Wang, Ph.D.Thomas Carroll, Ph.D.Yonghao Yu, Ph.D.The SPORE award builds upon discoveries fueled by competitive kidney cancer research funding from the Cancer Prevention and Research Institute of Texas and the National Institutes of Health.*Cancer Prevention and ResearchNational Institutes of Institute of Texas (CPRIT) Awards Health (NIH) Awards Research Projects Research Projects $21,625,685 $36,758,600Core Facilities Core Facilities$19,189,081 $ 68.8 $5,015,056 $ 41.7 Recruitment MILLION MILLION $28,050,000Leveraging breakthrough research, discovery, and technological innovation at UT Southwestern, the Kidney Cancer Program is one of two programs in the U.S. recognized by the National Cancer Institute as a Specialized Program of Research Excellence in kidney cancer, earning the prestigious *Apportioned amounts from 2013 (when Kidney SPORE Award. Cancer Program was founded) through 201912 13'