b'OverviewProgram Highlights 20061 With more than 120 physician and research faculty, possiblyDr. James Brugarolas, foundingthe largest kidney cancer program in the world. 1 Director of the Kidney Cancer 2 Survival rates triple the national benchmarks for stage 4Program, is recruited from the Dana- 2010Farber Cancer Institute/Harvard kidney cancer patients and are higher across stages. 2 A Robust Foundation Cancer Center to UT Southwestern.Peloton Therapeutics is co-founded 3 One of only two kidney cancer programs to receive aby Dr. Steve McKnight, Chair ofSpecialized Program of Research Excellence (SPORE)The Kidney Cancer Program is2011 the Biochemistry Department at 3 located at the Harold C. SimmonsUT Southwestern, to develop a Award from the National Cancer Institute. Comprehensive Cancer Center, onefirst-in-class drug targeting the of 51 National Cancer Institute- Immunologist Dr. Bruce Beutler isHIF-2 protein.4Only program to develop a new drug for kidney cancerawarded the Nobel Prize. going from gene discovery to clinical trials. 4 designated comprehensive cancer2013centers in the U.S. and one of 5One of two programs in the U.S. developingonly three in Texas. It is the only comprehensive cancer center inDallas Mayor Mike Rawlings immunotherapies with a Nobel Prize winner for immunologyinaugurates the Kidney research. 5 North Texas.2016 Cancer Program.6 Developed first classification of kidney cancer based on 6 UT Southwestern ranked No. 1 gene mutations, paving the way for tailored treatments. in the world by the prestigiousThe Kidney Cancer Program becomes Nature Index (2020)the second in the U.S. to earn the 7Broadest and most innovative radiation oncology programprestigious Specialized Program of20177 Research Excellence (SPORE) Award for kidney cancer. UT Southwestern is one of thefrom the National Cancer Institute.8 nations preeminent academicAn analysis by the UT Southwestern medical centers with an esteemedOffice of Quality Improvement shows 8 One of the first to develop kidney tumor ablation in the U.S.faculty of physicians and scientists2018 improved survival across stages 9 T compared to national rates. op 10 robotic kidney surgery program in the U.S. and largest in North Texas. 9 that includes:!4 Nobel Laureates Biochemist Dr. Zhijian James Chen ! 23 members of the Nationalis selected for the Breakthrough Prize 1As of January 2020, the Kidney Cancer Program comprised more than 30 dedicatedAcademy of Sciences in Life Sciences and develops a new2019physicians, over 90 collaborating physicians, and more than 100 investigators distributedimmunotherapy drug designed to across 19 research tracks.2Analysis from UTSW Quality Improvement Office compared to!17 members of the Nationalactivate the STING pathway.national SEER data.3NIH Kidney Cancer SPORE Program.4Discovered gene encodingAt the forefront of ushering new HIF-2 and developed an inhibitor, PT2385/PT2977, now in clinical trials. 5Two scientistsAcademy of Medicine technologies into practice for have been awarded a Nobel Prize for Immunology Research in the United States in the last 20 years, Dr. Bruce Beutler at UT Southwestern Medical Center and Dr. James!13 Howard Hughes Medical2020 treating advanced kidney cancer, Allison at University of Texas MD Anderson Cancer Center.6UT Southwestern investiga-tors reported: (i) discovery that the BAP1 gene is mutated in 15% of clear cell renal cellInstitute InvestigatorsUT Southwestern pioneers a carcinomas, the most common type of kidney cancer; (ii) mutations in BAP1 tend to begroundbreaking radiation strategy mutually exclusive with mutations in PBRM1; (iii) BAP1-deficient tumors are of high grade,Recognizing North Texas companies,for controlling metastatic whereas PBRM1-deficient tumors are of low grade; (iv) BAP1-deficient tumors are asso-ciated with poor survival whereas survival for patients with PBRM1-deficient tumors isentrepreneurs, and leadersdisease. In recognition of better; and (v) BAP1 and PBRM1 genes control cancer aggressiveness (Pea-Llopis, Natredefining their industries, the Kidneyits many innovations and Genet, 2012; Joseph, J Urol, 2016; Pea-Llopis, Cancer Res, 2013; Gu, Cancer Discov, 2017).7Largest reported experience of stereotactic body radiation therapy (SBRT) beyondCancer Program is a finalist for Dachievements, the Kidney the brain (Wang, Int J Radiat Oncol Biol Phys, 2017) and first to report its deploymentMagazine & D CEOs Innovation inCancer Program earns the for oligoprogression as well as tumor extensions into large veins (tumor thrombi) (Straka, J Clin Oncol, 2013; Hannan, Cancer Biol Ther, 2015). Search of national clinical trialsHealthcare Award. Leaders in Clinical Excellence registry (clinicaltrials.gov) with the terms Kidney Cancer and Stereotactic (December 1,Program Development Award for 2018) shows no other programs with similar breadth and number of active clinical trials.8Ogan, Urology, 2002.9DFW County Hospital District Database, 2016; Solucientadvanced patient care. Database, 2014. 8 9'