External Advisory Board adds new members
Prominent kidney cancer experts Elizabeth Plimack, M.D., M.S., and Rana McKay, M.D., are the newest members of the Kidney Cancer Program’s External Advisory Board. Established in 2014, the nine-member board comprises noted physicians and scientists from across the country who serve as resources on research initiatives for KCP leadership.
Dr. Plimack is Professor of Hematology/Oncology and Division Chief of Genitourinary Medical Oncology at Fox Chase Cancer Center in Philadelphia. Dr. McKay is Associate Professor of Medicine and Urology at the University of California-San Diego and Co-Leader of the Genitourinary Oncology Disease Team at Moores Cancer Center.
UTSW investigator identifies signaling pathway responsible for driving sarcomatoid differentiation
Molecular biologist Thomas Carroll, Ph.D., reports in the Journal of Clinical Investigation that activation of the Hippo/Warts pathway, one of the major signaling pathways regulating organ size and tissue growth, is sufficient to drive sarcomatoid renal cancer. In studies in mice, Carroll and colleagues show that constitutive activation of Hippo/Warts through deletion of Lats1/2 drives sarcomatoid tumors and metastases.