UTSW investigator identifies signaling pathway responsible for driving sarcomatoid differentiation
Molecular biologist Thomas Carroll, Ph.D., reports in the Journal of Clinical Investigation that activation of the Hippo/Warts pathway, one of the major signaling pathways regulating organ size and tissue growth, is sufficient to drive sarcomatoid renal cancer. In studies in mice, Carroll and colleagues show that constitutive activation of Hippo/Warts through deletion of Lats1/2 drives sarcomatoid tumors and metastases.
2019 Nobel Prize winner Dr. William Kaelin speaks at University Lecture Series
2019 Nobel Prize winner and Harvard Medical School Professor William Kaelin, M.D., is the guest speaker for UT Southwestern’s University Lecture Series. Kidney Cancer Program Director James Brugarolas, M.D., Ph.D., and Associate Professor of Pathology Qing Zhang, Ph.D., served as hosts. Dr. Kaelin is recognized for his landmark work involving the VHL tumor suppressor gene.