Highlights

Physicians and Researchers
120+

Physicians and Researchers

Possibly the largest kidney cancer program worldwide.1

Survival Rates
3x

Survival Rates

Stage 4 survival rates triple the national average;
higher across all stages.2

Kidney Cancer Programs Awarded
1 of only 2

Kidney Cancer SPORE Awards

Awarded a specialized Program of Research Excellence
(SPORE) Award from the National Cancer Institute.3

New Drug Development

New Drug Development

Only program to develop a drug going from gene discovery to FDA approval.4

Nobel Prize - Immunotherapy

Nobel Prize - Immunotherapy

One of only two U.S. programs developing immunotherapies with a
Nobel Laureate in immunology research.5

right-therapy

The Right Therapy for the Right Patient

Developed first comprehensive, integrated, molecular, genetic, and pathological classification of kidney cancer advancing precision medicine6

Radiation Expertise

Radiation Expertise

Possibly the broadest, most innovative radiation oncology program for kidney cancer.7

Pioneer in Ablation

Pioneer in Ablation

Among the first to develop kidney tumor ablation in the U.S.8

Leading Surgery Program

#1
Largest in North Texas8
Top 3
Urology department in U.S.9
Top 10
Robotic kidney surgery program in U.S.8

National Research Hub

REFERENCES
  • 1 As of January 2020, the Kidney Cancer Program comprised more than 30 dedicated physicians, over 90 collaborating physicians, and more than 100 investigators distributed across 19 research tracks.
  • 2 Analysis from UTSW Quality Improvement Office compared to national SEER data.
  • 3 NIH Kidney Cancer SPORE Program. Kidney SPOREs | TRP (cancer.gov)
  • Discovered HIF-2ɑ gene and developed drug receiving FDA approval in 2021.
  • 5 Two scientists have been awarded a Nobel Prize for Immunology Research in the United States in the last 20 years, Dr. Bruce Beutler at UT Southwestern Medical Center, and Dr. James Allison at University of Texas MD Anderson Cancer Center.
  • 6 UT Southwestern investigators reported: (i) discovery that the BAP1 gene is mutated in 15% of clear cell renal cell carcinomas, the most common type of kidney cancer; (ii) mutations in BAP1 tend to be mutually exclusive with mutations in PBRM1; (iii) BAP1-deficient tumors are of high grade, whereas PBRM1-deficient tumors are of low grade; (iv) BAP1-deficient tumors are associated with poor survival whereas survival for patients with PBRM1-deficient tumors is better; and (v) BAP1 and PBRM1 genes control cancer aggressiveness (Peña-Llopis, Nat Genet, 2012; Joseph, J Urol, 2016; Peña-Llopis, Cancer Res, 2013; Gu, Cancer Discov, 2017).
  • 7 Largest reported experience of stereotactic body radiation therapy (SBRT) beyond the brain (Wang, Int J Radiat Oncol Biol Phys, 2017) and first to report its deployment for oligoprogression as well as tumor extensions into large veins (tumor thrombi) (Straka et al., J Clin Oncol, 2013; Hannan, Cancer Biol Ther, 2015). Search of national clinical trials registry (clinicaltrials.gov) with the terms “Kidney Cancer” and “Stereotactic” (December 1, 2018) shows no other programs with similar breadth and number of active clinical trials.
  • 8 Source: DFW County Hospital District Database, 2016; Solucient Database.
  • 9 Third-party ranking using an Academic Score, see Kutikov, Eur Urol, 2012.
  • 10 UTSW No. 1 worldwide for published research in health care category by Nature Index (2020).
  • 11 Source: Sivanand et al., Sci Transl Med, 2012; Pavia-Jimenez et al., Nat Protoc, 2014.
  • 12 Source: Gu et al., Cancer Discovery, 2017.
  • 13Developed Kidney Cancer Explorer, a self-updating platform linking clinical information, experimental genomics and tumor samples.