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UTSW investigator identifies signaling pathway responsible for driving sarcomatoid differentiation

June 3, 2021
Discovery, Fundamental Research
Research

Molecular biologist Thomas Carroll, Ph.D., reports in the Journal of Clinical Investigation that activation of the Hippo/Warts pathway, one of the major signaling pathways regulating organ size and tissue growth, is sufficient to drive sarcomatoid renal cancer. In studies in mice, Carroll and colleagues show that constitutive activation of Hippo/Warts through deletion of Lats1/2 drives sarcomatoid tumors and metastases.

April 14, 2021
Lecture, Q&A, Research
HIF2, Targeted Drugs

2019 Nobel Prize winner Dr. William Kaelin speaks at University Lecture Series

April 14, 2021
HIF2, Targeted Drugs
Lecture, Q&A, Research

2019 Nobel Prize winner and Harvard Medical School Professor William Kaelin, M.D., is the guest speaker for UT Southwestern’s University Lecture Series. Kidney Cancer Program Director James Brugarolas, M.D., Ph.D., and Associate Professor of Pathology Qing Zhang, Ph.D., served as hosts. Dr. Kaelin is recognized for his landmark work involving the VHL tumor suppressor gene.