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Molecular biologist Thomas Carroll, Ph.D., reports in the Journal of Clinical Investigation that activation of the Hippo/Warts pathway, one of the major signaling pathways regulating organ size and tissue growth, is sufficient to drive sarcomatoid renal cancer. In studies in mice, Carroll and colleagues show that constitutive activation of Hippo/Warts through deletion of Lats1/2 drives sarcomatoid tumors and metastases.